Over the past 10 years, HIV infection rate has increased annually from 30% to 40% in China, resulting in over 700,000 Chinese living with HIV/AIDS by the end of 2007. The Chinese National Medium and Long-Term Strategic Plan for HIV/AIDS Control and Prevention (1998-2010) identifies the men who have sex with men (MSM) population as a high-risk group for HIV infection. The latest statistics show that MSM account for 11.1% of all HIV/AIDS cases in China, an alarming rising rate in a country with one fourth of the world's population. To help expanding the emerging foundation of scientific and empirical data on Chinese MSM, several multidivisional research initiatives have been initiated. For example, the China National Center for AIDS/STD Prevention and Control recently launched a national study targeting above 26,000 MSM in 61 cities in 2008. Other programs, targeted prevention measures for the estimated 5-10 million-Chinese MSM, including stronger promotion of condom use, expanded coverage and quality of HIV prevention activities, increased access to voluntary HIV counseling-and-testing services, and improved access to treatment for sexually transmitted infections. To complement these initiatives, this article aims to provide a comprehensive review and analysis of the (a) scientific and empirical literature (both in English and Chinese) on HIV/sexually tranmitted infection (STI) prevention targeting Chinese MSM, and (b) existing programmatic and policy efforts targeting Chinese MSM at risk for STIs (including HIV). Finally, four recommendations for future endeavors targeting this high-risk group are drawn from the above analyses.