G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer

Chem Commun (Camb). 2009 Nov 14:(42):6481-3. doi: 10.1039/b910242f. Epub 2009 Sep 14.

Authors

Keisuke Iida¹, Masayuki Tera, Takatsugu Hirokawa, Kazuo Shin-ya, Kazuo Nagasawa

Affiliation

¹ Department of Biotechnology and Life Science Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), Koganei, Tokyo 184-8588, Japan.

PMID: 19841816
DOI: 10.1039/b910242f

Abstract

Macrocyclic hexaoxazole (6OTD) dimers were designed as candidates for potent G-quadruplex binders and synthesized.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dimerization
G-Quadruplexes*
Macrocyclic Compounds / chemical synthesis
Macrocyclic Compounds / chemistry*
Oxazoles / chemical synthesis
Oxazoles / chemistry*
Spectrometry, Mass, Electrospray Ionization
Telomere / chemistry
Telomere / metabolism

Substances

Macrocyclic Compounds
Oxazoles