Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

Miguel F Ferreira; André F Martins; José A Martins; Paula M Ferreira; Eva Tóth; Carlos F G C Geraldes

doi:10.1039/b912201j

Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

Chem Commun (Camb). 2009 Nov 14:(42):6475-7. doi: 10.1039/b912201j. Epub 2009 Sep 9.

Authors

Miguel F Ferreira¹, André F Martins, José A Martins, Paula M Ferreira, Eva Tóth, Carlos F G C Geraldes

Affiliation

¹ Centro de Química, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

PMID: 19841814
DOI: 10.1039/b912201j

Abstract

We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-alpha-aminopropionate, and the relaxometric characterization of its Gd(3+) complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemical synthesis*
Contrast Media / chemistry
Gadolinium / chemistry*
Magnetic Resonance Imaging*
Organometallic Compounds / chemical synthesis*
Organometallic Compounds / chemistry
Water / chemistry*

Substances

Contrast Media
Organometallic Compounds
Water
Gadolinium