1,5-diazacyclohenicosane, a new cytotoxic metabolite from the marine sponge Mycale sp

Laura Coello; María Jesús Martín; Fernando Reyes

doi:10.3390/md7030445

1,5-diazacyclohenicosane, a new cytotoxic metabolite from the marine sponge Mycale sp

Mar Drugs. 2009 Sep 15;7(3):445-50. doi: 10.3390/md7030445.

Authors

Laura Coello¹, María Jesús Martín, Fernando Reyes

Affiliation

¹ Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain. lcoello@pharmamar.com

Abstract

A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the muM level against three human tumor cell lines.

Keywords: Mycale sp; alkaloids; cytotoxicity; marine sponges.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Heterocyclic Compounds, 1-Ring / isolation & purification
Heterocyclic Compounds, 1-Ring / pharmacology*
Humans
Kenya
Porifera / chemistry*
Spectrum Analysis / methods

Substances

1,5-diazacyclohenicosane
Antineoplastic Agents
Heterocyclic Compounds, 1-Ring