Abstract
The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus.
MeSH terms
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Animals
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Interferon Type I / immunology*
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Interferon Type I / metabolism
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Mice
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Monocytes / immunology*
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Toll-Like Receptor 2 / immunology*
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Toll-Like Receptor 2 / metabolism
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Vaccinia / immunology*
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Vaccinia virus / immunology
Substances
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Interferon Type I
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Tlr2 protein, mouse
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Toll-Like Receptor 2