TLR2 joins the interferon gang

Nat Immunol. 2009 Nov;10(11):1139-41. doi: 10.1038/ni1109-1139.

Abstract

The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Interferon Type I / immunology*
  • Interferon Type I / metabolism
  • Mice
  • Monocytes / immunology*
  • Toll-Like Receptor 2 / immunology*
  • Toll-Like Receptor 2 / metabolism
  • Vaccinia / immunology*
  • Vaccinia virus / immunology

Substances

  • Interferon Type I
  • Tlr2 protein, mouse
  • Toll-Like Receptor 2