Abstract
Nanoparticles loaded with two different commercial insulins (Actrapid, Novorapid and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit RS) were characterized in vitro. The zeta potential was positive whenever Eudragit RS was part of the nanoparticles matrix. The encapsulation efficiency was ~ 96% except for Novorapid-loaded particles of poly-epsilon-caprolactone (only 35%). In vitro release studies revealed a burst release from nanoparticles, which may be of interest for oral delivery. Novorapid-loaded nanoparticles were orally administered to diabetic rats and allowed the glycemia to be decreased when compared with free nanoparticles.
MeSH terms
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Acrylic Resins / administration & dosage
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Acrylic Resins / chemistry*
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Administration, Oral
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Animals
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Biocompatible Materials / administration & dosage
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Biocompatible Materials / chemistry*
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Blood Glucose / analysis
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / drug therapy
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Drug Carriers / administration & dosage
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Drug Carriers / chemistry*
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Drug Compounding
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Hypoglycemic Agents / administration & dosage*
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Hypoglycemic Agents / therapeutic use
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Insulin / administration & dosage
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Insulin / analogs & derivatives*
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Insulin / therapeutic use
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Insulin Aspart
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Insulin, Regular, Pork
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Male
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Nanoparticles / administration & dosage
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Nanoparticles / chemistry*
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Particle Size
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Polyesters / administration & dosage
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Polyesters / chemistry*
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Rats
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Rats, Wistar
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Streptozocin
Substances
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Acrylic Resins
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Biocompatible Materials
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Blood Glucose
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Drug Carriers
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Hypoglycemic Agents
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Insulin
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Insulin, Regular, Pork
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Polyesters
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polycaprolactone
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Eudragit RS
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Streptozocin
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insulin, neutral
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Insulin Aspart