Abstract
The Rad9-Hus1-Rad1 checkpoint clamp (9-1-1) is a central player in the cellular response to DNA damage; three groups have determined the crystal structure of 9-1-1, providing new insight into its loading mechanism and association with DNA damage checkpoint and repair enzymes.
MeSH terms
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / physiology*
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DNA Damage*
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DNA Repair*
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Exonucleases / chemistry
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Exonucleases / physiology*
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Models, Molecular
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Protein Structure, Tertiary
Substances
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Cell Cycle Proteins
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HUS1 protein, human
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HUS1B protein, human
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rad9 protein
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Exonucleases
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Rad1 protein, human