DNA distress: just ring 9-1-1

Curr Biol. 2009 Sep 15;19(17):R733-4. doi: 10.1016/j.cub.2009.07.026.

Abstract

The Rad9-Hus1-Rad1 checkpoint clamp (9-1-1) is a central player in the cellular response to DNA damage; three groups have determined the crystal structure of 9-1-1, providing new insight into its loading mechanism and association with DNA damage checkpoint and repair enzymes.

MeSH terms

  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / physiology*
  • DNA Damage*
  • DNA Repair*
  • Exonucleases / chemistry
  • Exonucleases / physiology*
  • Models, Molecular
  • Protein Structure, Tertiary

Substances

  • Cell Cycle Proteins
  • HUS1 protein, human
  • HUS1B protein, human
  • rad9 protein
  • Exonucleases
  • Rad1 protein, human