5HT3-antagonist receptors: their role in drug-induced emesis

Nouv Rev Fr Hematol (1978). 1990;32(6):449-52.

Abstract

Chemotherapy-induced emesis is the most severe side effect in term of patient's perception. Current anti-emetic regimen as high dose metoclopramide can achieve a complete response in less than 60% of patients. The HT3 receptors appear to be the principal mediator of the emetic effect and their blockade have a clear activity in the prevention of acute drug-induced emesis, superior to reference regimens.

Publication types

  • Review

MeSH terms

  • Antiemetics / classification
  • Antiemetics / pharmacology
  • Antiemetics / therapeutic use*
  • Antineoplastic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Dexamethasone / therapeutic use
  • Dopamine Antagonists
  • Drug Evaluation
  • Drug Therapy, Combination
  • Humans
  • Metoclopramide / pharmacology
  • Metoclopramide / therapeutic use
  • Receptors, Serotonin / classification
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology*
  • Serotonin Antagonists / pharmacology*
  • Serotonin Antagonists / therapeutic use
  • Vomiting / chemically induced*
  • Vomiting / drug therapy
  • Vomiting / physiopathology

Substances

  • Antiemetics
  • Antineoplastic Agents
  • Antipsychotic Agents
  • Dopamine Antagonists
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Dexamethasone
  • Metoclopramide