Susceptibility of strains of Bacteroides fragilis group (1284 isolates from cancerous and noncancerous patients in 1994-2004) showed an increase in resistance toward some antibiotics (by 9 % toward penicillin and 8 % toward clindamycin) compared with the resistance level of 10 years ago. The increase in resistance was not detected in the case of ampicillin + sulbactam and metronidazole.