Abstract
Using an acoustic method we showed that the aptamer configuration, especially those comprised of dimers with binding exosites sensitive to heparin and fibrinogen at thrombin, substantially increases the aptasensor sensitivity.
Publication types
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Acoustics*
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Aptamers, Nucleotide / chemistry*
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Aptamers, Nucleotide / metabolism
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Binding Sites
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Biosensing Techniques / methods*
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Nucleic Acid Conformation
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Protein Binding
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Sensitivity and Specificity
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Thrombin / analysis*
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Thrombin / metabolism
Substances
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Aptamers, Nucleotide
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Thrombin