Pancreatic beta-cell and gut regulatory peptide responses were investigated in 13 healthy elderly and 12 young subjects (control group) after a standard meal test. In addition to hyperinsulinemia and hypergastrinemia, we found lower basal and postprandial total integrated responses (TIR) for gastric inhibitory polypeptide and bombesin in the elderly group. The mean postprandial TIR for neurotensin (NT) was significantly higher in the aged subjects, but the somatostatin response was suppressed in this group.