Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction

Chem Commun (Camb). 2009 Nov 7:(41):6195-7. doi: 10.1039/b913785h. Epub 2009 Sep 14.

Abstract

A novel alpha-diazo imide reagent and its activation by strong Brønsted acid is shown to produce the product of a syn-glycolate Mannich transform with high diastereoselection.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acids / chemistry
  • Glycolates / chemistry*
  • Imides / chemistry*
  • Stereoisomerism

Substances

  • Acids
  • Glycolates
  • Imides
  • glycolic acid