Abstract
This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimony / blood
-
Antiprotozoal Agents / administration & dosage
-
Antiprotozoal Agents / therapeutic use*
-
Kidney / parasitology
-
Kidney / pathology
-
Leishmania braziliensis
-
Leishmaniasis, Cutaneous / drug therapy*
-
Leishmaniasis, Cutaneous / parasitology
-
Leishmaniasis, Cutaneous / pathology
-
Liver / parasitology
-
Liver / pathology
-
Macaca mulatta
-
Meglumine / administration & dosage
-
Meglumine / therapeutic use*
-
Meglumine Antimoniate
-
Organometallic Compounds / administration & dosage
-
Organometallic Compounds / therapeutic use*
-
Spleen / parasitology
-
Spleen / pathology
Substances
-
Antiprotozoal Agents
-
Organometallic Compounds
-
Meglumine
-
Meglumine Antimoniate
-
Antimony