Neuroblastoma involvement of the falx cerebri

Pediatr Blood Cancer. 2009 Dec 15;53(7):1337-9. doi: 10.1002/pbc.22192.

Abstract

Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challenging. We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / drug therapy
  • Adrenal Gland Neoplasms / pathology*
  • Adrenal Gland Neoplasms / surgery
  • Adrenalectomy
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carboplatin / administration & dosage
  • Cell Lineage
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Dura Mater / pathology*
  • Etoposide / administration & dosage
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Meningeal Neoplasms / drug therapy
  • Meningeal Neoplasms / secondary*
  • Microphthalmia-Associated Transcription Factor / genetics
  • Neoplasm Staging
  • Neural Crest
  • Neuroblastoma / drug therapy
  • Neuroblastoma / genetics
  • Neuroblastoma / pathology
  • Neuroblastoma / secondary*
  • Neuroblastoma / surgery
  • Pulmonary Veins / abnormalities
  • Remission Induction
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / secondary
  • Waardenburg Syndrome / complications
  • Waardenburg Syndrome / genetics

Substances

  • MITF protein, human
  • Microphthalmia-Associated Transcription Factor
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Carboplatin