A 42-year-old woman presented with chronic cough and dyspnea. A leiomyoma of the right middle lobe of the bronchus was diagnosed by bronchoscopic biopsy and treated successfully by neodymium-yttrium aluminum garnet laser, via fiberoptic bronchoscope. The presentations of bronchial leiomyoma are mainly due to partial or complete occlusion of the involved bronchus. Symptoms are mainly cough, wheeze, chest pain and fever, as a result of atelectasis, consolidation, collapse or bronchiectasis. The management of this benign tumor of the lung is discussed, and the importance of early diagnosis and conservative therapy are emphasized.