Draft genome sequences of Yersinia pestis isolates from natural foci of endemic plague in China

J Bacteriol. 2009 Dec;191(24):7628-9. doi: 10.1128/JB.01227-09. Epub 2009 Oct 9.

Abstract

To gain insights into the evolutionary origin, emergence, and pathogenicity of the etiologic agent of plague, we have sequenced the genomes of four Yersinia pestis strains isolated from the zoonotic rodent reservoir in foci of endemic plague in China. These resources enable in-depth studies of Y. pestis sequence variations and detailed whole-genome comparisons of very closely related genomes from the supposed site of the origin and the emergence of global pandemics of plague.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • China / epidemiology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics*
  • Disease Reservoirs
  • Endemic Diseases*
  • Genome, Bacterial*
  • Humans
  • Molecular Sequence Data
  • Plague / epidemiology*
  • Plague / microbiology
  • Rodentia / microbiology
  • Sequence Analysis, DNA*
  • Yersinia pestis / genetics*
  • Yersinia pestis / isolation & purification

Substances

  • DNA, Bacterial

Associated data

  • GENBANK/AAYT01000000
  • GENBANK/AAYU01000000
  • GENBANK/AAYV01000000
  • GENBANK/ABAT01000000