Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT

Bioorg Med Chem. 2009 Nov 15;17(22):7647-57. doi: 10.1016/j.bmc.2009.09.048. Epub 2009 Sep 29.

Abstract

This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzene Derivatives / chemical synthesis
  • Benzene Derivatives / chemistry*
  • Benzene Derivatives / pharmacology
  • Benzene Derivatives / therapeutic use
  • Biological Assay
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Female
  • Glucose / analogs & derivatives
  • Glucose / chemistry*
  • Glucose / pharmacology
  • Glucose / therapeutic use
  • Humans
  • Models, Chemical
  • Photochemotherapy / methods*
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / pharmacology
  • Photosensitizing Agents / therapeutic use*
  • Polyamines / chemistry*
  • Polyamines / pharmacology
  • Polyamines / therapeutic use
  • Porphyrins / chemistry*
  • Porphyrins / pharmacology
  • Porphyrins / therapeutic use

Substances

  • Benzene Derivatives
  • Photosensitizing Agents
  • Polyamines
  • Porphyrins
  • Glucose