Arginine-pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections

Dieter Haebich; Hein-Peter Kroll; Hans-Georg Lerchen

doi:10.1016/j.bmcl.2009.09.090

Arginine-pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6317-8. doi: 10.1016/j.bmcl.2009.09.090. Epub 2009 Sep 27.

Authors

Dieter Haebich¹, Hein-Peter Kroll, Hans-Georg Lerchen

Affiliation

¹ Medicinal Chemistry, Bayer Schering Pharma AG, D-42096 Wuppertal, Germany. dieter.haebich@bayerhealthcare.com

PMID: 19819137
DOI: 10.1016/j.bmcl.2009.09.090

Abstract

Arginine-pyrimidine conjugates represent a novel class of compounds that exhibits therapeutic and prophylactic activity in lethal infections by Gram-positive and Gram-negative bacteria without showing antibacterial activity in vitro.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Arginine / chemistry
Arginine / pharmacology*
Bacterial Infections / drug therapy
Cross Infection / drug therapy*
Drug Interactions
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria / drug effects
Methicillin Resistance
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests*
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Streptococcal Infections / drug therapy

Substances

Anti-Bacterial Agents
Pyrimidines
Arginine