The current review summarizes the characteristics of existing experimental models for intracranial atherosclerosis in rabbits, pigs, and dogs with potential implications for research. New methodologies for understanding plaque morphology, and plaque quantitation and its prognostic implications are important for risk stratification in regards to ischemic events and lesion progression. A potential treatment strategy for intracranial atherosclerotic disease may be aimed at medical therapies that induce plaque regression. The treatment with statins to stabilize and/or promote plaque regression of intracranial atherosclerotic lesions is largely inferred from data in the coronary literature. In patients with multisegmented intracranial atherosclerotic diseases with no other therapeutic option, angiogenic growth factors may represent a new venue.