DNA double-strand breaks come into focus

Karl-Peter Hopfner

doi:10.1016/j.cell.2009.09.017

DNA double-strand breaks come into focus

Cell. 2009 Oct 2;139(1):25-7. doi: 10.1016/j.cell.2009.09.017.

Author

Karl-Peter Hopfner¹

Affiliation

¹ Center for Integrated Protein Science Munich and Munich Center for Advanced Photonics at the Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. hopfner@lmb.uni-muenchen.de

PMID: 19804750
DOI: 10.1016/j.cell.2009.09.017

Abstract

The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.

Publication types

Comment

MeSH terms

Cell Cycle Proteins / chemistry*
DNA Breaks, Double-Stranded*
DNA Repair*
Humans
Nuclear Proteins / chemistry*
Schizosaccharomyces / chemistry
Schizosaccharomyces pombe Proteins / chemistry*
Schizosaccharomyces pombe Proteins / metabolism

Substances

Cell Cycle Proteins
Nuclear Proteins
Schizosaccharomyces pombe Proteins