Learning how to read ADP-ribosylation

Henning Kleine; Bernhard Lüscher

doi:10.1016/j.cell.2009.09.018

Learning how to read ADP-ribosylation

Cell. 2009 Oct 2;139(1):17-9. doi: 10.1016/j.cell.2009.09.018.

Authors

Henning Kleine¹, Bernhard Lüscher

Affiliation

¹ Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany.

PMID: 19804746
DOI: 10.1016/j.cell.2009.09.018

Abstract

ADP-ribosylation is a posttranslational modification that is emerging as a broadly used mechanism to regulate the functions of proteins and their interactions. Recent findings by three groups (Ahel et al., 2009; Gottschalk et al., 2009; Timinszky et al., 2009) establish that proteins with macrodomains bind poly-ADP-ribose to mediate the cellular response to DNA damage.

MeSH terms

ADP Ribose Transferases / metabolism
Animals
DNA Repair*
Humans
Poly Adenosine Diphosphate Ribose / metabolism*
Protein Processing, Post-Translational*
Proteins / metabolism*

Substances

Proteins
Poly Adenosine Diphosphate Ribose
ADP Ribose Transferases