Abstract
Multicentric Castleman disease (MCD) is a rare human herpes virus type 8 (HHV8)-associated lymphoproliferative disorder that occurs more frequently in patients infected with human immunodeficiency virus (HIV). In tissue samples, HHV8-infected plasmablasts localise to the mantle zones of the lymphoid follicles. We revisited the immunohistological features in 25 lymph node (LN) and three spleen samples of MCD. In five (20%) LN and one (33%) spleen sample, HHV8 latent nuclear antigen 1 (LANA1) staining was also noted on the follicular dendritic cells (FDC). The HHV8-positive FDC subgroup of patients had significantly higher numbers of CD3-positive T cells infiltrating the follicles when compared to the HHV8-negative FDC subgroup (P = 0.047). Furthermore, the numbers of HHV8-positive plasmablasts and serum HHV8 viral copy numbers were lower among the HHV8-positive FDC subgroup when compared to the HHV8-negative FDC subgroup (not statistically significant). Our findings show, for the first time, possible 'presentation' of an HHV8 antigen by FDCs in MCD.
MeSH terms
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Adult
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Aged
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Antigens, Viral / immunology*
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Antigens, Viral / metabolism
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CD3 Complex / immunology
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CD3 Complex / metabolism
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Castleman Disease / complications
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Castleman Disease / immunology*
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Castleman Disease / metabolism
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Castleman Disease / pathology
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Castleman Disease / virology
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Dendritic Cells / pathology
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Dendritic Cells / virology
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Female
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HIV / immunology*
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HIV / metabolism
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HIV Infections / complications
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HIV Infections / immunology*
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HIV Infections / metabolism
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HIV Infections / pathology
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HIV Infections / virology
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Herpesviridae Infections / complications
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Herpesviridae Infections / immunology*
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Herpesviridae Infections / metabolism
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Herpesviridae Infections / pathology
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Herpesviridae Infections / virology
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Herpesvirus 8, Human / immunology
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Herpesvirus 8, Human / metabolism
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Humans
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Lymph Nodes / immunology
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Lymph Nodes / metabolism
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Lymph Nodes / pathology
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Lymph Nodes / virology
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Male
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Middle Aged
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Nuclear Proteins / immunology*
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Nuclear Proteins / metabolism
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Spleen / immunology
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Spleen / metabolism
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Spleen / pathology
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Spleen / virology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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T-Lymphocytes / pathology
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T-Lymphocytes / virology
Substances
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Antigens, Viral
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CD3 Complex
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Nuclear Proteins
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latency-associated nuclear antigen