Abstract
Due to high reactivity, reactive oxygen species can attack biological molecules leading to cell or tissue injury. In this study, glucose moiety was attached at the C-7 position of quercetin 3-O-methyl ether (1) and luteolin (2) through glycosidic bond or ether linkage. The glucose-containing compounds showed potent DPPH and superoxide anion radical scavenging and lipid peroxidation inhibition activities and nearly equivalent protective actions to the parent aglycons against the H2O2-induced oxidative neuronal damage in primary cultured rat cortical cells. Among the compounds tested, 3b and 3c were the most potent (IC50 values=7.33 and 5.34 microM, respectively), exhibiting nearly equivalent actions to the parent compounds 1 and 2 (IC50=3.50 and 3.75 microM, respectively).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Flavones / chemical synthesis*
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Flavones / chemistry
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Flavones / pharmacology
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Free Radical Scavengers / chemical synthesis*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Glucosides / chemical synthesis*
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Glucosides / chemistry
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Glucosides / pharmacology
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Hydrogen Peroxide / metabolism
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Lipid Peroxidation
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Luteolin / chemical synthesis*
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Luteolin / chemistry
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Luteolin / pharmacology
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology
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Quercetin / analogs & derivatives*
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Quercetin / chemical synthesis
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Quercetin / chemistry
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Quercetin / pharmacology
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Rats
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Reactive Oxygen Species / metabolism
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Xanthine Oxidase / antagonists & inhibitors
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Xanthine Oxidase / metabolism
Substances
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Enzyme Inhibitors
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Flavones
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Free Radical Scavengers
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Glucosides
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Neuroprotective Agents
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Reactive Oxygen Species
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quercetin 3-O-methyl ether
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Quercetin
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Hydrogen Peroxide
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Xanthine Oxidase
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Luteolin