Antibiotic-induced severe neutropenia with multidrug-dependent antineutrophil antibodies developed in a child with Streptococcus pneumoniae infection

J Korean Med Sci. 2009 Oct;24(5):975-8. doi: 10.3346/jkms.2009.24.5.975. Epub 2009 Sep 23.

Abstract

Drug-induced neutropenia (DIN), particularly that in which antibiotic-dependent antineutrophil antibodies have been detected, is a rare disorder. We report the case of a child with pneumococcal pneumonia, who experienced severe neutropenia during various antibiotic treatments. We detected 4 kinds (cefotaxim, augmentin, vancomycin, and tobramycin) of antibiotic-dependent antineutrophil antibodies by using the mixed passive hemagglutination assay (MPHA) technique with this child.

Keywords: Anti-Bacterial Agents; Antineutrophil Antibody; Neutropenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Antibodies, Antineutrophil Cytoplasmic / immunology
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Drug Therapy, Combination
  • Humans
  • Infant
  • Male
  • Neutropenia / chemically induced
  • Neutropenia / diagnosis*
  • Pneumonia, Pneumococcal / complications
  • Pneumonia, Pneumococcal / drug therapy*
  • Tomography, X-Ray Computed

Substances

  • Anti-Bacterial Agents
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies