Abstract
From the genetic standpoint, T-lineage acute lymphoblastic leukemia is a heterogeneous disease and comprises a number of different subtypes. In this perspective article, Dr. Mullighan analyzes the relationship between somatic mutations in NOTCH1 or FBXW7 and the prognosis of T-lineage acute lymphoblastic leukemia. See related article on page 1383.
MeSH terms
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Cell Cycle Proteins / genetics*
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Cell Lineage / physiology
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F-Box Proteins / genetics*
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F-Box-WD Repeat-Containing Protein 7
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Humans
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Mutation / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Prognosis
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Receptor, Notch1 / genetics*
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T-Lymphocytes / pathology*
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Ubiquitin-Protein Ligases / genetics*
Substances
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Cell Cycle Proteins
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F-Box Proteins
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F-Box-WD Repeat-Containing Protein 7
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FBXW7 protein, human
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NOTCH1 protein, human
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Receptor, Notch1
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Ubiquitin-Protein Ligases