Mutations of NOTCH1, FBXW7, and prognosis in T-lineage acute lymphoblastic leukemia

Haematologica. 2009 Oct;94(10):1338-40. doi: 10.3324/haematol.2009.012047.

Abstract

From the genetic standpoint, T-lineage acute lymphoblastic leukemia is a heterogeneous disease and comprises a number of different subtypes. In this perspective article, Dr. Mullighan analyzes the relationship between somatic mutations in NOTCH1 or FBXW7 and the prognosis of T-lineage acute lymphoblastic leukemia. See related article on page 1383.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Cell Cycle Proteins / genetics*
  • Cell Lineage / physiology
  • F-Box Proteins / genetics*
  • F-Box-WD Repeat-Containing Protein 7
  • Humans
  • Mutation / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Receptor, Notch1 / genetics*
  • T-Lymphocytes / pathology*
  • Ubiquitin-Protein Ligases / genetics*

Substances

  • Cell Cycle Proteins
  • F-Box Proteins
  • F-Box-WD Repeat-Containing Protein 7
  • FBXW7 protein, human
  • NOTCH1 protein, human
  • Receptor, Notch1
  • Ubiquitin-Protein Ligases