Magnetic wire traps and programmable manipulation of biological cells

Phys Rev Lett. 2009 Sep 18;103(12):128101. doi: 10.1103/PhysRevLett.103.128101. Epub 2009 Sep 17.

Abstract

We present a multiplex method, based on microscopic programmable magnetic traps in zigzag wires patterned on a platform, to simultaneously apply directed forces on multiple fluid-borne cells or biologically inert magnetic microparticles or nanoparticles. The gentle tunable forces do not produce damage and retain cell viability. The technique is demonstrated with T-lymphocyte cells remotely manipulated (by a joystick) along desired trajectories on a silicon surface with average speeds up to 20 microm/s.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cobalt / chemistry
  • Cytological Techniques / methods*
  • Electromagnetic Phenomena*
  • Humans
  • Iron / chemistry
  • Magnetics
  • Microscopy / methods*
  • Nanoparticles / chemistry
  • T-Lymphocytes / cytology

Substances

  • Cobalt
  • Iron