Gestational age-specific cutoff levels of TDx-FLM II for the prediction of neonatal respiratory distress syndrome

Fetal Diagn Ther. 2009;25(4):392-6. doi: 10.1159/000236152. Epub 2009 Sep 29.

Abstract

Aim: To construct a predictive model for respiratory distress syndrome (RDS) from gestational age (GA) at delivery and TDx-FLM II value.

Methods: Pregnant women who underwent an amniocentesis in which TDx-FLM II was determined were included in the study. A model for the occurrence of RDS was constructed by means of a logistic regression procedure from TDx-FLM II values and GA at delivery.

Results: The mean value of TDx-FLM II was 47.11 mg/g. The mean GA at delivery was 33.4 weeks. The incidence of RDS was 7.8% (18/231). The optimal cutoff of predicted risk for respiratory distress was found to be 8.8%, resulting in a sensitivity and specificity of 89 and 83%, respectively.

Conclusions: The adjustment of the TDx-FLM II value for GA at delivery results in a significant improvement in the predictive capacity of the test for the occurrence of RDS. The use of GA-specific cutoff values may simplify clinical decisions.

MeSH terms

  • Albumins / analysis*
  • Amniocentesis
  • Amniotic Fluid / chemistry*
  • Female
  • Fetal Organ Maturity*
  • Fluorescence Polarization
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Logistic Models
  • Lung / embryology*
  • Models, Biological
  • Predictive Value of Tests
  • Pregnancy
  • Pulmonary Surfactants / analysis*
  • ROC Curve
  • Respiratory Distress Syndrome, Newborn / diagnosis*
  • Respiratory Distress Syndrome, Newborn / etiology
  • Respiratory Distress Syndrome, Newborn / metabolism
  • Risk Assessment
  • Risk Factors
  • Sensitivity and Specificity

Substances

  • Albumins
  • Pulmonary Surfactants