Abstract
Here we report the clinical features and treatment outcomes of three patients with Candida haemulonii infection. Candida haemulonii was confirmed by sequence analysis of the internal transcribed spacer (ITS) regions of the rRNA genes and the 18S rRNA genes. Two of the three isolates were associated with fungaemia and reduced susceptibility to fluconazole [minimum inhibitory concentrations (MICs) of 16 mg/L] and amphotericin B (MICs of 2 mg/L). However, one of these two patients responded to fluconazole therapy. Echinocandins, voriconazole and posaconazole demonstrated excellent in vitro potency against the isolates.
MeSH terms
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Aged
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Aged, 80 and over
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Candida / classification*
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Candida / drug effects*
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Candida / genetics
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Candida / isolation & purification
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Candidiasis / drug therapy*
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Candidiasis / microbiology*
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Candidiasis / pathology
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Cluster Analysis
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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DNA, Ribosomal Spacer / chemistry
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DNA, Ribosomal Spacer / genetics
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Drug Resistance, Fungal
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Genes, rRNA
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Humans
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Male
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Microbial Sensitivity Tests
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Mycological Typing Techniques
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RNA, Fungal / genetics
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RNA, Ribosomal, 18S / genetics
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Sequence Analysis, DNA
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Treatment Outcome
Substances
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Antifungal Agents
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DNA, Fungal
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DNA, Ribosomal
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DNA, Ribosomal Spacer
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RNA, Fungal
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RNA, Ribosomal, 18S