A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria

Molecules. 2009 Sep 21;14(9):3694-9. doi: 10.3390/molecules14093694.

Abstract

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiaris / chemistry*
  • Cardenolides / isolation & purification*
  • Cardenolides / pharmacology*
  • Cardiac Glycosides / isolation & purification*
  • Cardiac Glycosides / pharmacology*
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Humans
  • Latex / chemistry*
  • Magnetic Resonance Spectroscopy

Substances

  • Cardenolides
  • Cardiac Glycosides
  • Latex
  • toxicarioside H