Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): efficient catalysts for the cyanosilylation and cyanocarbonation of aldehydes and ketones

Molecules. 2009 Sep 2;14(9):3353-9. doi: 10.3390/molecules14093353.

Abstract

A variety of aldehydes and ketones were transformed to their corresponding cyanohydrin silyl ethers in good to excellent yields in the presence of 1-5 mol% of tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP). Cyanohydrin carbonates were also readily prepared using 5-10 mol% of TTMPP as an organocatalyst.

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Ketones / chemistry*
  • Nitriles / chemistry*
  • Phosphines / chemistry*
  • Silanes / chemistry*

Substances

  • Aldehydes
  • Ketones
  • Nitriles
  • Phosphines
  • Silanes
  • tris(2,4,6-trimethoxyphenyl)phosphine