Conjugate addition of indoles to alpha,beta-unsaturated ketones using a Brønsted acid ionic liquid as an efficient catalyst

Molecules. 2009 Aug 27;14(9):3222-8. doi: 10.3390/molecules14093222.

Abstract

The Brønsted acid ionic liquid [PyN(CH(2))(4)SO(3)H][p-CH(3)PhSO(3)] has been reported as an efficient catalyst for the Michael addition reaction of indoles to alpha,beta-unsaturated ketones. Satisfactory results were obtained, with excellent yields and a simple experimental procedure. The catalyst could be recycled and reused up to three times without any noticeable decrease in the catalytic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry*
  • Catalysis
  • Chalcone / chemistry
  • Indoles / chemistry*
  • Ionic Liquids / chemistry*
  • Ketones / chemical synthesis
  • Ketones / chemistry*

Substances

  • Acids
  • Indoles
  • Ionic Liquids
  • Ketones
  • Chalcone