Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

Ronny Schmidt; Bernd Bukau; Axel Mogk

doi:10.1016/j.resmic.2009.08.018

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

Res Microbiol. 2009 Nov;160(9):629-36. doi: 10.1016/j.resmic.2009.08.018. Epub 2009 Sep 22.

Authors

Ronny Schmidt¹, Bernd Bukau, Axel Mogk

Affiliation

¹ Zentrum für Molekulare Biologie Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Universität Heidelberg, Im Neuenheimer Feld 282, Heidelberg D-69120, Germany.

PMID: 19781640
DOI: 10.1016/j.resmic.2009.08.018

Abstract

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine Triphosphatases / metabolism*
Biocatalysis
Carrier Proteins / metabolism
Escherichia coli / enzymology*
Escherichia coli / metabolism
Escherichia coli Proteins / metabolism*
Peptide Hydrolases / metabolism*
Protein Stability
Proteins / metabolism
Substrate Specificity

Substances

Carrier Proteins
ClpS protein, E coli
Escherichia coli Proteins
Proteins
Peptide Hydrolases
Adenosine Triphosphatases