Straightforward synthesis of the near-infrared fluorescent voltage-sensitive dye RH1691 and analogues thereof

Org Lett. 2009 Nov 5;11(21):4822-5. doi: 10.1021/ol901846g.

Abstract

A highly straightforward synthesis of the near-infrared voltage-sensitive dye RH1691 is reported featuring two sequential anionic additions of C-nucleophilic heterocycles on a cyanine. This convergent approach led to the synthesis of four new probes, which also exhibit fluorescence in the near-infrared region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescence
  • Fluorescent Dyes / chemical synthesis
  • Infrared Rays
  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Thiazoles / chemical synthesis*
  • Thiazoles / chemistry

Substances

  • Fluorescent Dyes
  • Pyrazoles
  • RH1691
  • Thiazoles