VopF, a type III effector protein from a non-O1, non-O139 Vibrio cholerae strain, demonstrates toxicity in a Saccharomyces cerevisiae model

J Med Microbiol. 2010 Jan;59(Pt 1):17-24. doi: 10.1099/jmm.0.012336-0.

Abstract

VopF, a type III effector protein, has been identified as a contributory factor to the intestinal colonization of type III secretion system-positive, non-O1, non-O139 Vibrio cholerae strains. To gain more insight into the function of VopF, a yeast model was developed. Using this model, it was found that ectopic expression of VopF conferred toxicity in yeast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Fungal / physiology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Vibrio cholerae non-O1 / classification*
  • Vibrio cholerae non-O1 / genetics
  • Vibrio cholerae non-O1 / metabolism*
  • Virulence
  • Virulence Factors / genetics*

Substances

  • Bacterial Proteins
  • Virulence Factors