Syntheses and configuration determination of (+)-villatamines A and B, two marine natural products

Lin Hu; Lihe Zhang; Hongbin Zhai

doi:10.1021/jo901606r

Syntheses and configuration determination of (+)-villatamines A and B, two marine natural products

J Org Chem. 2009 Oct 2;74(19):7552-5. doi: 10.1021/jo901606r.

Authors

Lin Hu¹, Lihe Zhang, Hongbin Zhai

Affiliation

¹ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Rd, Beijing 100083, China.

PMID: 19778083
DOI: 10.1021/jo901606r

Abstract

The first total syntheses of (+)-villatamines A and B have been realized in six and five steps, respectively. The stereogenic center present in these two naturally occurring alkaloids should have an (S)-configuration based on our results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Factors / chemical synthesis*
Biological Factors / chemistry*
Molecular Conformation
Pyrrolidines / chemical synthesis*
Pyrrolidines / chemistry*
Stereoisomerism

Substances

Biological Factors
Pyrrolidines
villatamine A
villatamine B