Abstract
Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.
MeSH terms
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Albizzia / chemistry*
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Cameroon
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Drug Screening Assays, Antitumor
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HCT116 Cells
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HT29 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Saponins* / chemistry
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Saponins* / isolation & purification
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Saponins* / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification
Substances
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Antineoplastic Agents, Phytogenic
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Saponins
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Triterpenes
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coriarioside A
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coriarioside B
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gummiferaoside C
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oleanane
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Oleanolic Acid