A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis

Ma Diarey B Tianero; Novriyandi Hanif; Nicole J de Voogd; Rob W M van Soest; Junichi Tanaka

doi:10.1002/cbdv.200800199

A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis

Chem Biodivers. 2009 Sep;6(9):1374-7. doi: 10.1002/cbdv.200800199.

Authors

Ma Diarey B Tianero¹, Novriyandi Hanif, Nicole J de Voogd, Rob W M van Soest, Junichi Tanaka

Affiliation

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

PMID: 19774600
DOI: 10.1002/cbdv.200800199

Abstract

A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / toxicity
Cell Line
Fatty Acids, Unsaturated / chemistry*
Fatty Acids, Unsaturated / isolation & purification
Fatty Acids, Unsaturated / toxicity
Microbial Sensitivity Tests
Porifera / chemistry*
Rats
Thiophenes / chemistry*
Thiophenes / isolation & purification
Thiophenes / toxicity

Substances

6-(5-((5E)-oct-5-en-7-ynyl)thiophen-2-yl)hex-5-ynoic acid
Anti-Infective Agents
Fatty Acids, Unsaturated
Thiophenes