Abstract
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / metabolism
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Crystallography, X-Ray
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Cyclization
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Humans
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Molecular Conformation
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Nevirapine / chemical synthesis*
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Nevirapine / chemistry
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Nevirapine / metabolism
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Rats
Substances
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Anti-HIV Agents
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Nevirapine