Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Ilona Wandzik; Tadeusz Bieg; Marianna Czaplicka

doi:10.1016/j.bioorg.2009.08.001

Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Bioorg Chem. 2009 Dec;37(6):211-6. doi: 10.1016/j.bioorg.2009.08.001. Epub 2009 Aug 15.

Authors

Ilona Wandzik¹, Tadeusz Bieg, Marianna Czaplicka

Affiliation

¹ Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Poland. ilona.wandzik@polsl.pl

PMID: 19765794
DOI: 10.1016/j.bioorg.2009.08.001

Abstract

A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine beta-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Galactosyltransferases / antagonists & inhibitors
Galactosyltransferases / metabolism
Glycosyltransferases / metabolism*
Substrate Specificity
Uridine Diphosphate Sugars / chemical synthesis*
Uridine Diphosphate Sugars / chemistry

Substances

Enzyme Inhibitors
Uridine Diphosphate Sugars
Glycosyltransferases
Galactosyltransferases