Development of herpes simplex virus stomatitis during receipt of cidofovir therapy

Clin Infect Dis. 2009 Oct 15;49(8):e92-5. doi: 10.1086/605678.

Abstract

We report 3 children who, after undergoing hematopoietic stem cell transplant, developed herpes simplex virus (HSV) stomatitis while receiving weekly cidofovir as preemptive treatment for cytomegalovirus infection. All patients responded well to treatment with either acyclovir or ganciclovir. Despite the in vitro susceptibility of HSV to cidofovir, once-weekly treatment with this agent may not be adequate prophylaxis in pediatric patients.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / therapeutic use
  • Antiviral Agents / therapeutic use*
  • Chemoprevention / methods*
  • Child
  • Child, Preschool
  • Cidofovir
  • Cytomegalovirus Infections / prevention & control
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Ganciclovir / therapeutic use
  • Humans
  • Male
  • Organophosphonates / therapeutic use*
  • Simplexvirus / isolation & purification*
  • Stem Cell Transplantation
  • Stomatitis / drug therapy
  • Stomatitis / virology*
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir
  • Ganciclovir
  • Acyclovir