Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum

J Nat Prod. 2009 Oct;72(10):1879-83. doi: 10.1021/np9003849.

Abstract

Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chromones / chemistry
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • Drug Screening Assays, Antitumor
  • HCT116 Cells
  • HL-60 Cells
  • Humans
  • Malaysia
  • Meliaceae / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Chromones