Abstract
Why consider the concept of the vulnerable parameter in a series on "Noninvasive Risk Assessment in Guiding Therapy for Prevention of Sudden Death?" Preceding that question might be, "what is the vulnerable parameter?" In the following pages, we shall review the history behind the concept of the vulnerable parameter, its evolution after its initial identification, where it stands today, and finally, why the vulnerable parameter is important to our consideration of risk factors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Action Potentials / drug effects
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Anti-Arrhythmia Agents / administration & dosage
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Anti-Arrhythmia Agents / pharmacology
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Anti-Arrhythmia Agents / therapeutic use*
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Arrhythmias, Cardiac / diagnosis
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Arrhythmias, Cardiac / drug therapy
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Arrhythmias, Cardiac / etiology*
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Arrhythmias, Cardiac / metabolism
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Death, Sudden, Cardiac / etiology*
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Death, Sudden, Cardiac / prevention & control*
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Drug Design
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Humans
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Ion Channels / metabolism
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Myocardium / metabolism
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Risk Assessment
Substances
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Anti-Arrhythmia Agents
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Ion Channels