Obesity is an important healthcare problem. Steady increase in its prevalence is observed worldwide. The underlying cause of obesity is mainly increased calories intake. The regulation of appetite is held by the hypothalamus. Satiety signals are sent to central nervous system via vagus due to distension of the walls of digestive tract and secretion of cytokine signaling after meal digestion. Additionally leptin excreted from adipose tissue reflects the state of energy storage and affects the hypothalamus. The study presents the literature on hormonal regulation of feeding.