Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

Qianli Wang; Jie Xue; Zhongwu Guo

doi:10.1039/b907351e

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

Chem Commun (Camb). 2009 Oct 7:(37):5536-7. doi: 10.1039/b907351e. Epub 2009 Aug 27.

Authors

Qianli Wang¹, Jie Xue, Zhongwu Guo

Affiliation

¹ Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.

Abstract

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adjuvants, Immunologic / chemical synthesis*
Adjuvants, Immunologic / chemistry
Antigens, Tumor-Associated, Carbohydrate / chemistry*
Cancer Vaccines / chemical synthesis*
Cancer Vaccines / chemistry
Lipid A / analogs & derivatives*
Lipid A / chemistry
Neuraminidase / chemistry*
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry
Structure-Activity Relationship

Substances

Adjuvants, Immunologic
Antigens, Tumor-Associated, Carbohydrate
Cancer Vaccines
Lipid A
Oligosaccharides
GM3 ganglioside sialidase
Neuraminidase
monophosphoryl lipid A

Abstract

Publication types

MeSH terms

Substances

Grants and funding