G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer

Nucleic Acids Symp Ser (Oxf). 2009:(53):233-4. doi: 10.1093/nass/nrp117.

Abstract

Telomestatin (TMS: 1) is as a potent and selective telomeric G-quadruplex binder. Two molecules of TMS were suggested to be intercalated to one telomeric G-quadruplex according to docking study. In this paper, we designed and synthesized hexaoxazole TMS derivative (6OTD) dimer, and evaluated its G-quadruplex stabilizing ability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry
  • Fluorescence Resonance Energy Transfer
  • G-Quadruplexes*
  • Oxazoles / chemical synthesis
  • Oxazoles / chemistry*
  • Telomere / chemistry*
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry*

Substances

  • Oxazoles
  • Thiazoles
  • telomestatin
  • DNA