5'-Lipophilic conjugates of oligonucleotides as components of cell delivery systems

A A Iglina; M I Meschaninova; A G Venyaminova

doi:10.1093/nass/nrp061

5'-Lipophilic conjugates of oligonucleotides as components of cell delivery systems

Nucleic Acids Symp Ser (Oxf). 2009:(53):121-2. doi: 10.1093/nass/nrp061.

Authors

A A Iglina¹, M I Meschaninova, A G Venyaminova

Affiliation

¹ Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia.

PMID: 19749290
DOI: 10.1093/nass/nrp061

Abstract

The approach to the synthesis of 5'-lipophilic conjugates of functional nucleic acids based on a combination of H-phosphonate and phosphoramidite methods is presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Lipids / chemistry*
Oligonucleotides / chemical synthesis*
Oligonucleotides / chemistry
Organophosphonates / chemistry
Organophosphorus Compounds / chemistry

Substances

Lipids
Oligonucleotides
Organophosphonates
Organophosphorus Compounds
phosphoramidite