Abstract
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC(50)=2.0-6.5 microM, but no cytotoxic effect was observed (IC(50)>100 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / isolation & purification
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Amides / pharmacology*
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Amides / therapeutic use
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Antioxidants / therapeutic use
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Cell Line, Tumor
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Heterocyclic Compounds, 2-Ring / isolation & purification
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Heterocyclic Compounds, 2-Ring / pharmacology*
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Heterocyclic Compounds, 2-Ring / therapeutic use
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Humans
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Immunologic Factors / isolation & purification
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Immunologic Factors / pharmacology*
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Immunologic Factors / therapeutic use
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Inhibitory Concentration 50
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Lignans / isolation & purification
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Lignans / pharmacology*
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Lignans / therapeutic use
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Male
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Phagocytosis / drug effects*
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Plant Bark
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Stems
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Prostatic Neoplasms / drug therapy
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Respiratory Burst / drug effects*
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Rutaceae / chemistry*
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Zymosan / blood
Substances
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Amides
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Heterocyclic Compounds, 2-Ring
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Immunologic Factors
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Lignans
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Plant Extracts
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heitziamide A
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heitziamide B
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heitziethanoid A
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heitziethanoid B
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Zymosan