We report a 79 year-old mate with a history of an acute coronary syndrome subjected to coronary angioplasty and stent placement in the right coronary artery (RCA) four months ago. Since the patient continued with symptoms, a coronary angiography was performed. During the procedure, the patient developed a cutaneous allergic reaction and bronchospasm probably related to contrast media and a severe spasm of the RCA with inferior ST elevation in the absence of restenosis, that was difficult to treat. The presence of angina or an acute coronary syndrome and allergic reactions is known as the Kounis syndrome.