The purpose of this study is to model and optimize the detection of tar in cigarettes during the manufacturing process and show that low yield cigarettes contain similar levels of nicotine as compared to high yield cigarettes while B (Benzene), T(toluene) and X (xylene) (BTX) levels increase with increasing tar yields. A neuro-fuzzy system which comprises a fuzzy inference structure is used to model such a system. Given a training set of samples, the Adaptive Neuro-Fuzzy Inference System (ANFIS) classifiers learned how to differentiate a new case in the domain. The ANFIS classifiers were used to detect the tar in smoke condensate when five basic features defining cigarette classes indications were used as inputs. A classical method by High Performance Liquid Chromatography (HPLC) is also introduced to solve this problem. At last the performances of these two methods are compared.