Inhibitors of osteoclast formation from rhizomes of Cibotium barometz

J Nat Prod. 2009 Sep;72(9):1673-7. doi: 10.1021/np9004097.

Abstract

Eight compounds (1-8) were isolated from a methanol extract of Cibotium barometz rhizomes including two new furan derivatives, cibotiumbarosides A (1) and B (2), and a new glycoglycerolipid, cibotiglycerol (4). Their structures were elucidated by chemical and spectroscopic methods. Compounds 2-5 each showed inhibition of osteoclast formation with no affect on BMM cell viability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ferns / chemistry*
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Glycolipids / chemistry
  • Glycolipids / isolation & purification*
  • Glycolipids / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Osteoclasts / drug effects*
  • Rhizome / chemistry
  • Vietnam

Substances

  • Furans
  • Glycolipids
  • Glycosides
  • cibotiglycerol
  • cibotiumbaroside A
  • cibotiumbaroside B
  • glycerolglycolipids